Abstract
THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS Thamer A Hamdan , Mubder A Mohammed Saeed & Abbas Salman Ismael Abstract Many studies suggested a relation between denervation and fracture healing either in positive or negative effect. This is a prospective experimental study on 20 rabbits carried out in the experimental animal’s research laboratory of Basrah University, Medical College from April 2014 to November 2014 according to ethical rules of institution. They were housed under controlled conditions of temperature and lighting, same diet was given for all animals. The rabbits was divided into two groups; group A with sciatic denervation and fracture of the tibia while group B, with fracture tibia only. The state of fracture healing was studied radiologically after 4 weeks and histopathologically at 6 weeks. The results showed significant difference between the two groups, the denervated group had poor fracture healing compared with non denervated group. In conclusion, denervation affects fracture healing negatively in rabbits.
Highlights
Peripheral denervation is claimed to delay healing of experimental fractures1,2, but opposing opinions have been presented3,4
Bould M et al22 said that it is possible to identify an end point of healing by measuring the callus score and the time of occurrence of this end point will be different for different fracture treatment and the callus score can usually be measured from standard radiographs that are obtained during the routine follow up of most fractures
He used the digital image for evaluation of fracture healing which shown to be up to 20 times more accurate, so we depend on digital radiograph to measure the callus score
Summary
Peripheral denervation is claimed to delay healing of experimental fractures, but opposing opinions have been presented. The effects of peripheral nerve lesions on callus formation at the fracture site are incompletely known. Fibular fractures failed to unite after removal of proprioceptive receptors by periosteal stripping. In human samples with delayed union or nonunion of diaphyseal fractures, the most remarkable finding was the insufficiency or total lack of peripheral innervation. Supporting these concepts are the observations that patients with neurologic disorders exhibit altered fracture healing and excessive callus formation. Dyck et al showed that patients with neuropathic arthropathy due to subclinical sensory neuropathy suffer from recurrent long bone fractures
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