Abstract
As evidenced by comparison with oxalate‐treated controls, the formation of radialsegmented lymphocyte and monocyte nuclei in oxalated blood is efficiently inhibited by the colchicine derivative demecolcine in a concentration (1.76 times 10‐7M) slightly above the minimum one required to ensure mitotic arrest in metaphase. This finding is discussed in relation to known data about the dynamics and action mechanism of colchicine and colchicine analogs. It is proposed that the influence of demecolcine on the oxalate‐induced radial segmentation might be explained by the hypothesis that radial segmentation is the result of a contraction of fibrous structures radiating from the centrosomal region, presumably interphasic remnants of the mitotic spindle.
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