Abstract
The secretion of hCG, progesterone, estradiol, estrone, DHA (dehydroepiandrosterone) and androstenedione was studied in tissue culture of human midterm placenta. Radioimmunoassay and gas-liquid chromatography were used in hormone measurements. Considerable amounts of progesterone and hCG were secreted during the 18-day cultivation period. The secretion of estrogen. DHA and androstenedione was minimal. The addition of DHA or DHAS (dehydroepiandrosterone sulphate) clearly increased estrogen secretion at all stages of cultivation, while hCG secretion was not affected. The results demonstrate the high capacity of placenta to convert adrenal androgens into estrogens, and they also confirm our earlier reports on the important regulatory function of placenta on peculiar steroidogenesis of human foetal adrenals.
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