The Effect of Deep Brain Stimulation on Perceptual Decision Making: A Psychophysical Study

Abstract

Event Abstract Back to Event The Effect of Deep Brain Stimulation on Perceptual Decision Making: A Psychophysical Study Nikos Green1, 2, 3*, Ann Kristin Beyer1, Rafal Bogacz4, Julius Huebl5, Andrea Kuehn5 and Hauke R. Heekeren1, 3, 6 1 Freie Universität Berlin, Department of Education and Psychology, Germany 2 Humboldt- Universität zu Berlin, Berlin School of Mind and Brain, Germany 3 Max Planck Institute for Human Development, Research Group "Neurocognition of Decision-Making", Germany 4 University of Bristol, Department of Computer Science, United Kingdom 5 Charité University Medicine Berlin, Department of Neurology, Germany 6 Freie Universität Berlin, Cluster of Excellence "Languages of Emotion", Germany We studied the effect of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on perceptual decision making in (so far n = 6) patients with Parkinson's disease (PD). Neurocomputational models (Bogacz 2009, Frank et al. 2007) on the function of the STN in the basal ganglia network during decision making have proposed that the STN plays a crucial role by sending a breaking signal to the output structures of the basal ganglia during the decision phase. This has an effect on sensorimotor transformations in PD patients, as during DBS this signal might be impaired leading to faster (i.e. impulsive) responding during high conflict choices. To investigate the role of the STN on decision adaptation in perceptual decision making, we used an instructed Speed Accuracy Tradeoff (SAT) task design with the moving dots stimulus. Preliminary results indicate that stimulation had a significant effect on response accuracy (RA) and reaction time (RT). Participant’s behavior differed significantly between On and Off DBS stimulation (RTon < RToff) along distinct dimensions such as response instruction and stimulus coherence. In line with previous work (Frank et al. 2007, Bogacz 2009) these results speak for a disinhibition of responses in perceptual decision making during DBS stimulation. Keywords: Deep Brain Stimulation, Parkinson, perceptual decision making, STN Conference: Decision Neuroscience From Neurons to Societies, Berlin, Germany, 23 Sep - 25 Sep, 2010. Presentation Type: Poster Topic: Perceptual Decision Making Citation: Green N, Beyer A, Bogacz R, Huebl J, Kuehn A and Heekeren HR (2010). The Effect of Deep Brain Stimulation on Perceptual Decision Making: A Psychophysical Study. Front. Neurosci. Conference Abstract: Decision Neuroscience From Neurons to Societies. doi: 10.3389/conf.fnins.2010.82.00011 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Aug 2010; Published Online: 07 Sep 2010. * Correspondence: Dr. Nikos Green, Freie Universität Berlin, Department of Education and Psychology, Berlin, Germany, nikos.green@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nikos Green Ann Kristin Beyer Rafal Bogacz Julius Huebl Andrea Kuehn Hauke R Heekeren Google Nikos Green Ann Kristin Beyer Rafal Bogacz Julius Huebl Andrea Kuehn Hauke R Heekeren Google Scholar Nikos Green Ann Kristin Beyer Rafal Bogacz Julius Huebl Andrea Kuehn Hauke R Heekeren PubMed Nikos Green Ann Kristin Beyer Rafal Bogacz Julius Huebl Andrea Kuehn Hauke R Heekeren Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.