The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.

Lindsey Miller,Bhagwat Prasad,Kari Thompson,Carolina Pavlenco,Hans Haverkamp,Abdul Basit,Samantha Skaufel,Julie Larsen,Vijaya Mettu

doi:10.3390/nu13103620

Lindsey Miller, Bhagwat Prasad + Show 7 more

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https://doi.org/10.3390/nu13103620

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Abstract

Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity-related diseases in humans have not been investigated. Therefore, the purpose of this investigation was to determine whether MSM supplementation improves cardiometabolic health, and markers of inflammation and oxidative status. A randomized, double-blind, placebo-controlled design was utilized with a total of 22 overweight or obese adults completing the study. Participants received either a placebo (white rice flour) or 3 g MSM daily for 16 weeks. Measurements occurred at baseline and after 4, 8, and 16 weeks. Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status. The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013). Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol.

Highlights

Introduction published maps and institutional affilMore than seventy percent of the adult population aged 20 and over is classified as overweight or obese in the Unites States [1]
Consumption resulted an were lower in group compared the placebo group at C-reactive protein (CRP)
Animal models suggest that MSM may improve insulin sensitivity and glucose regulation

Summary

Introduction

Introduction published maps and institutional affilMore than seventy percent of the adult population aged 20 and over is classified as overweight or obese in the Unites States [1]. Overweight and obesity are associated with chronic inflammation and oxidative stress, which contributes to metabolic dysfunction and various pathologies including type 2 diabetes, cardiac fibrosis and cardiovascular disease (CVD) [2,3,4,5,6,7,8], referred to collectively as cardiometabolic disease. Overweight or obesity alone is a risk factor for cardiometabolic diseases, the presence of metabolic dysfunction, known as metabolically unhealthy overweight/obesity, further increases risk for the development of CVD and type 2 diabetes compared to individuals with metabolically healthy overweight/obesity [9,10,11,12,13,14]. The precise definition of ‘metabolically unhealthy’ has varied in the literature, the most common definition is based upon the presence of metabolic syndrome [9]. Federation as the presence of three or more of the following risk factors: central obesity iations.

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