Abstract
Objective: The dopaminergic and endothelin systems play important roles in the control of blood pressure by regulating sodium transport in the renal proximal tubule (RPT). Deletion of the ETB receptor or D3 receptor gene in rats results in salt-sensitive hypertension with impaired sodium excretion. We will investigate whether there is an interaction between D3 and ETB receptors and its effect on sodium excretion in Wistar–Kyoto rats. Methods: D3 or ETB receptor agonists and/or antagonists were infused selectively into the right kidney of anesthetized WKY rats. The renal function, especially the sodium excretion, was checked in WKY rats with or without reagent treatment. Results: Activation of D3 receptor with D3 receptor agonist (PD128907) increased sodium excretion in WKY rats, which could be blocked by D3 receptor antagonist, GR103691. Although ETB receptor antagonist BQ788, by itself, had no effect on sodium excretion, The D3 receptor-mediated natriuresis was partially blocked by BQ788. Conclusions: The natriuretic effect of D3 receptor is partially via ETB receptor in WKY rats.
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