Abstract
Problem of diagnosis and treatment of patients with necrotizing pancreatitis is an urgent. So it is interesting to study the effectiveness of a multicomponent antihypoxant and antioxidant cytoflavin to reduce violations of the detoxifying properties of the liver in experimental pancreatitis and reduce the severity of pancreatic endotoxemia. Pancreatic modeled by introducing into the pancreas of autobile in a dose of 0,15 ml/kg. Cytoflavin was injected into animals of a comparison group in a dose 0,21 ml/kg in 5 minutes after the model of pancreatic necrosis. We determined the activity of enzymes: alanine transaminase, amylase, and gamma glutamyltransferase, the content of direct bilirubin, glucose, and urea. After modeling of pancreatic necrosis in two days, there are signs of acute liver failure, as evidenced by the differences in the studied parameters of blood and hepatic portal vein: increased alanine transaminase and gamma glutamyltransferase, the change in concentration of metabolic products, such as direct bilirubin and urea. In addition, decreased glucose levels. Introduction of cytoflavin approached the control values the basic biochemical parameters of liver function: decreased hyperenzymemia, exchange function of the liver was restored, which is probably due to antihypoxic, membrane and antioxidant effects of the drug.
Highlights
С учетом актуальности проблемы диагностики и лечения больных с панкреонекрозом представляет интерес изучение эффективности использования многокомпонентного антигипоксанта и антиоксиданта цитофлавина для уменьшения нарушений детоксицирующих свойств печени при экспериментальном панкреонекрозе и снижения тяжести панкреатогенной эндотоксемии
Cytoflavin was injected into animals of a comparison group in a dose 0,21 ml/kg in 5 minutes after the model of pancreatic necrosis
We determined the activity of enzymes: alanine transaminase, amylase, and gamma glutamyltransferase, the content of direct bilirubin, glucose, and urea
Summary
Влияние цитофлавина на функционально-метаболические показатели печени крыс при панкреонекрозе. С учетом актуальности проблемы диагностики и лечения больных с панкреонекрозом представляет интерес изучение эффективности использования многокомпонентного антигипоксанта и антиоксиданта цитофлавина для уменьшения нарушений детоксицирующих свойств печени при экспериментальном панкреонекрозе и снижения тяжести панкреатогенной эндотоксемии. After modeling of pancreatic necrosis in two days, there are signs of acute liver failure, as evidenced by the differences in the studied parameters of blood and hepatic portal vein: increased alanine transaminase and gamma glutamyltransferase, the change in concentration of metabolic products, such as direct bilirubin and urea. Цель исследования — оценить эффективность использования многокомпонентного антигипоксанта и антиоксиданта цитофлавина для уменьшения нарушений детоксицирующих свойств печени при экспериментальном панкреонекрозе и снижения тяжести панкреатогенной эндотоксемии [5]
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