Abstract
The effect of cyclosporine (CsA) treatment in both primary and secondary Chlamydia trachomatis ocular infection in cynomolgus monkeys was studied. Following primary infection, CsA-treated animals developed severe clinical symptoms which persisted for up to 12 weeks compared to control animals which developed less severe inflammation lasting only 4 to 6 weeks. CsA treatment had no effect on the clinical course of a second ocular infection. Antigen-specific antibodies developed normally in the serum and tears of all animals, but the titer of IgM in serum and secreted IgA in tears of CsA-treated animals was significantly lower than control animals. Chlamydia-specific cell-mediated immunity, as determined by in vitro lymphoproliferation assays of peripheral blood, did not develop in either group of animals.
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