Abstract
The repeated application of 2-aminoanthracene (2-AA) to the skin of rats produces tumors derived from both epithelial structures and connec-, tive tissue (1). Although basal cell epitheliomas are most frequent, squamous cell carcinomas and ! fibrosarcomas also occur. Usually two or more varieties of tumor are present in the same animal. These circumstances, therefore, provide an opportunity to observe the effects of an antitumor agent on a number of distinct tumors simultaneously in the same animal. Cyclophosphamide (CP) has been widely used in the treatment of neoplastic diseases. It has an effect on epithelial carcinomas as well as tumors of mesodermal origin (2). Because of its broad-spectrum of action, cyclophosphamide was selected for this study.
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