Abstract
Extract of fruit pulp of Cucumis metuliferus was screened for its effects on gastric functions and mucosal intergrity in albino rats. The study revealedsignificant (P < 0.05) dose-dependent decrease in the number and type of gastro mucosal lesions as compared to ranitidine (a standard anti-gastric ulcer drug). Similarly, the effect of the extract on gastric acid secretion was significant (P < 0.05). The results of this work showed that extract of Cucumismetuliferus significantly reduces gastro mucosal lesions and can be use for the treatment of peptic ulcer disease.
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