Abstract
The kinetics of the dopaquinone cyclization in the absence and presence of Cu(II) ions at pHs from 6 to 7.4 has been studied by cyclic, normal and reverse pulse voltammetry. Distinct inhibition of the dopaquinone ring closure reaction was observed in the. presence of Cu(II) ions. At pHs below 6 this effect is attributed to the formation of amino acid type complexes. At pH 7.4 the amino acid type and the catechol type Cu(II)-DOPA chelates coexist, and simultaneous interactions of copper ions with both ends of the DOPA molecule result in the association of the Cu(II)-DOPA complexes. These effects, observed at physiological pH, suggest that the rate of melanin formation is affected by the presence of Cu(II) ions.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
