Abstract
Effects of tuberculin upon leukocytes from patients with tuberculosis were described in 1909 by Achard and Benard [1]. In 1932, Rich and Lewis [2] demonstrated that tuberculin inhibited the normal migration of leukocytes from animals with delayed hypersensitivity to tuberculin. Their work also demonstrated that this effect did not occur in immediate hypersensitivity such as anaphylaxis or the Arthur phenomenon and established this tissue culture technique as a valuable tool for detecting delayed hypersensitivity. Many workers who have studied delayed hypersensitivity have confirmed this in-vitro phenomenon [3-6]. The work of Heilman and Feldman [5] on anergic states demonstrated the presence of delayed hypersensitivity as measured by the leukocytic migration test in dying tuberculous animals after the loss of dermal hypersensitivity; this and later studies [6] on experimental brucellosis showed the superiority of the leukocytic migration test over dermal sensitivity methods.
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