Abstract
Background: The purpose of the present study was to investigate the changes of malondialdehyde, dopamine and glutathione peroxidase in the hippocampus of rats with Parkinson's disease: a comparison of two types of continuous and interval aerobic exercise. Methods: In this study, 30 male Wistar rats weighing 250 to 350 g were used. Subjects were treated with reserpine for Parkinson's disease and divided into 6 groups and 5 rats each. Then the exercises were performed for 6 weeks. At the end of training, rats were anesthetized using ketamine and xylazine, hippocampal tissue was isolated, and malondialdehyde, dopamine, and glutathione peroxidase (GPX) were measured. The results were analyzed using one-way ANOVA and Bonferroni post hoc test. Results: The results of this study showed that 6 weeks of interval aerobic exercise showed a significant decrease in the levels of malondialdehyde in Parkinson's model rats (p ≤0.05), but continuous exercise did not show a significant decrease (p ≥0.05), as well as continuous and interval aerobic training significantly increased dopamine levels (p ≤0.05). They showed no difference between the two types of exercise (p ≥0.05). Intermittent aerobic exercise increases glutathione peroxidase levels in parkinsonian rats (p ≤0.05). But continuous training did not have a significant effect (p ≥0.05). Conclusion: According to the findings of this study, it can be concluded that interval aerobic exercise can be used to improve MDA and GPX and continuous and interval exercise to improve dopamine in Parkinson's patients.
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