The effect of complex sanatorium treatment on the level of β2-microglobulin serum and urine in children with chronic pyelonephritis

Abstract

The aim : to study the effect of various integrated spa treatment schemes on the β 2 -microglobulin (β 2 MG) dynamics of blood serum and urine in children with various clinical forms of chronic pyelonephritis (CP). Patients and methods . 254 children with CP, aged 6 to 16 years were included in the study. Secondary CP was diagnosed in 205 (80.71 %) children, primary CP was diagnosed in 49 (19.29 %) children. Patients were randomized into 5 groups: 1 group (n = 48) - comparison group. Spa treatment included a sanatorium-resort regimen, diet 5, physiotherapy, climatotherapy, phytotherapy and balneotherapy. Patients of all subsequent groups, in addition to basic therapy, received peloidotherapy. Children of the 2 group (n = 56) received 6 procedures of galvanopeloidotherapy on the projection area of the; children of 3 group (n = 54) - received 10 procedures of amplipulse peloid therapy on the projection area of the kidneys. Children of the 4 group children (n = 46) received 10 procedures of mud applications on the panty zone. Children of the 5 group 5 (n = 50) received 8 procedures of mud applications on the lumbar projection area. Determined p2-MG in serum and urine using standard sets "DRG int., Inc.", USA. Results. In patients with secondary CP before treatment, an increase in p2-MG in both biological media was diagnosed, in patients with primary CP, only in urine. On the background of a comprehensive spa treatment, the urine β 2 -MG concentration in patients with primary CP was statistically significantly reduced in all groups. Normalized - in 2, 3 and 5 groups. Patients of groups 2 and 3 had a significant difference from the result of the comparison group. In patients with secondary CP 3, the β 2-MG group in both biological media reached reference values. In group 4, it was normalized in serum and significantly reduced in urine. In groups 1,2 and 5, there was no significant change in the level of urine β 2 -MG in urine, and in serum there was only in group 5. Conclusion. For normalization of serum β 2 -MG and urine in patients with CP it is advisable to conduct peloidotherapy. The area of mud exposure, duration, combination with the preformed physical factor is determined individually, depending on the clinical form of CP.