Abstract
Background Endometriosis is a chronic and estrogen-dependent pelvic inflammatory disease, which may have various causes, such as oxidative stress. Dysmenorrhea, dyspareunia, and pelvic pain are well-known symptoms of endometriosis. The present clinical trial assessed the role of supplementation with antioxidant vitamins on the indices of oxidative stress as well as the severity of pain in women with endometriosis. Materials and Methods We enrolled 60 reproductive-aged (15–45 years) women with pelvic pain in this triple-blind clinical trial. They had 1–3 stages of laparoscopic-proven endometriosis. The participants were randomized to group A (n = 30), given vitamin C (1000 mg/day, 2 tablets of 500 mg each) and vitamin E (800 IU/day, 2 tablets of 400 IU each) combination, or group B (n = 30), given placebo pills daily for 8 weeks. Results Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. There was no significant decline in total antioxidant capacity after treatment. However, the severity of pelvic pain (p value <0.001), dysmenorrhea (p value <0.001), and dyspareunia (p value <0.001) significantly decreased in the treatment group after 8 weeks of supplementation. Conclusions The present findings support the potential role of antioxidants in the management of endometriosis. The intake of vitamin C and vitamin E supplements effectively reduced dysmenorrhea severity and improved dyspareunia and severity of pelvic pain.
Highlights
Endometriosis (EMS) is a chronic and estrogen-dependent pelvic inflammatory disease that arises from ectopic endometrial implantation and growth outside the uterus cavity [1]
Since adjuvant therapy by antioxidants such as vitamin C and vitamin E in EMS requires additional human clinical trials [22], this study aimed to evaluate the effect of vitamin C and vitamin E coadministration on oxidative stress (OS) markers well as pain severity in women with endometriosis
Methods is randomized placebo-controlled clinical trial was carried out on 60 reproductive-aged (15–45 years) women with pelvic pain and 1–3 stages of laparoscopic-proven endometriosis referred to Sarem Hospital in northwest of Tehran city, Capital of Iran, from June to November 2017. e Iran University of Medical Sciences Ethical Committee approved this research protocol, and all women signed an informed consent form, after they informed completely about study goals and methods. e trial protocol was registered in the Iranian Registry of Clinical trials (IRCT201106296917N1)
Summary
The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Leila Amini ,1,2 Razieh Chekini ,3 Mohammad Reza Nateghi, Hamid Haghani, Tannaz Jamialahmadi, Thozhukat Sathyapalan, and Amirhossein Sahebkar 9,10,11. Received 8 February 2021; Revised 8 May 2021; Accepted 15 May 2021; Published 26 May 2021
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