Abstract
Purpose/Objective: Intensity-modulated radiation therapy (IMRT) shows significant potential for improving the cancer survival rate by offering a powerful tool for tumor dose escalation and normal tissue toxicity reduction. Currently, IMRT is mainly implemented on a clinical linear accelerator (LINAC) equipped with a multileaf collimator (MLC). The goal of IMRT treatment planning is to determine a control sequence of the LINAC and the MLC to create a conformal radiation dose distribution inside the patient by optimizing (1) gantry rotation angles, (2) couch rotation angles, (3) MLC leaf positions, and (4) MLC rotation angles.
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