Abstract
The effect of prolonged 3°C. temperature stress upon the growth of tumors in the submandibular glands of albino rats was studied. Pellets of 9, 10-dimethyl 1, 2-benzanthracene were implanted in the right submandibular glands of forty-eight experimental animals, and twenty-four of these animals were placed in a cold room for the duration of the experiment; the remaining animals were maintained at room temperature. Epidermoid carcinomas developed in all submandibular glands containing the carcinogen. Microscopic study revealed that the tumors developed in both groups of animals at about the same time. However, once the tumors developed, the growth rate was accelerated in the cold animals and larger lesions developed. The increased metabolism resulting from the prolonged cold stress could be responsible for increasing the growth rate of tumors. Also, cold stress may act to stimulate tumor growth by depressing antibody formation.
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