Abstract
Previous studies showed that neural stem cells (NSCs) have an ability to differentiate into neurons, astrocytes and oligodendrocytes. However, the mechanisms that govern the fate of neural stem cell determination have not yet been fully clarified. In this study, we demonstrated that expression and activation of cofilin 1, a F-actin depolymerizing factor, are significantly changed during the development of brain, cortex or NSCs. Using Neuro-2a cells as a model, we found that overexpression of cofilin 1 significantly inhibit the cell differentiation and neurite outgrowth, while inhibition of intracellular cofilin 1 phosphorylation was significantly promoted. In cultured NSCs, we observed that cofilin 1 reduced the proportion of neurons derived from NSC due to inhibition of the phosphorylation, while the morphological maturation of neurons was promoted. Together, our findings revealed that cofilin 1 plays dynamic regulatory role on NSC cell fate determination and enhance neuronal maturation through regulating its activity and expression.
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