The effect of coenzyme Q10 supplementation on oxidative stress status and insulin resistance in diabetic rats

Abstract

Background and Aim: Coenzyme Q10 is an antioxidant it is now used in diseases associated with oxidative stress. Given the importance of oxidative stress in the complications of diabetes, this study aimed to investigate the effect of CoQ10 supplementation on the status of oxidative stress and insulin resistance was performed in diabetic rats. Materials and Methods: 18 Sprague-Dawley male rats were randomly divided into 3 groups (n=6). The control group received the physiological serum, the diabetic group (STZ: 55 mg/kg) received sesame oil, and the supplement group, which was diabetic, received Q10 intraperitoneal (i.p) at a dose of 2 mg/kg per day for 10 days. At the end of the tenth day, a venous blood sample was collected. Plasma levels of glucose, insulin, vitamin D, total antioxidant capacity, malondialdehyde (MDA), and protein thiol groups were measured using the corresponding colorimetric methods. Results: The results showed that treatment of diabetic rats with CoQ10 supplementation significantly reduced fasting blood sugar (FBS) and MDA levels and significantly increased serum insulin and vitamin D levels compared to diabetic rats (P<0.05).The average weight, thiol groups, insulin resistance, and total antioxidant capacity in the treated diabetic rats with CoQ10 supplementation varied compared with the diabetic control group but were not significant (p>0.05). Conclusion: Consumption of CoQ10 supplementation can reduce the oxidative stress caused by diabetes through its antioxidant effects. Key Words: Antioxidant; Coenzyme Q10; Diabetes Mellitus; Vitamin D