Abstract
The adjuvant arthritic rat (AAR) and experimental allergic encephalomyelitic rat (EAE) are models for studying inflammatory reactions triggered by immunologic processes (1–3). In the AAR the disease manifests itself in a systemic inflammation which can be evaluated by measuring the swelling of the hind paws. In the EAE the inflammation encompasses the myelin sheath which results in hind limb paralysis. Although there are similarities between these two models, the response varies according to the classes of drugs. Anti-inflammatory drugs, both steroidal and nonsteroidal as well as immunosuppressants are active in the AAR while only steroids and immunosuppressants are active in the EAE (4,5).
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