Abstract
Multiparous rats develop a spontaneous arteriosclerosis. The effect of clofibrate on the incidence and severity of the disease was studied in breeding female rats each of which had had 6 litters. Clofibrate was administered in the diet at a level of 0.25%. Groups of treated rats were killed after 3, 6 and 12 months' treatment with a similar number of controls at each time. The aortas were dissected out from heart to diaphragm, radiographed and examined histologically. The kidneys, adrenals, heart, liver, and ovaries of each animal were also examined histologically. The results of the experiments demonstrated that clofibrate decreases the severity and incidence of the disease. Its chief effect appears to be to reduce the calcification and mucopolysaccharide content of the aorta. There is no correlation between arteriosclerosis and kidney disease but clofibrate also reduces the incidence of nephropathy. Histological changes in the adrenal glands were less severe in the clofibrate treated rats.
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