Abstract
SummaryThe effect of clofibrate (ethyl-p-chlorophenoxyisobutyrate) on adenyl cyclase activity in rat liver, epididymal fat, and jejunum has been studied. Rats fed a diet high in fructose with 1% clofibrate had a statistically significant decrease in adenyl cyclase activity in all the tissues tested. There was no effect on the phosphodiesterase activity in the membrane preparation used for the adenyl cyclase assay. When clofibrate was added to the incubation media there was no inhibition of the adenyl cyclase activity in the control animal tissues.This finding is consistent with the hypothesis that the lipid-lowering action of clofibrate may be through its inhibition of adenyl cyclase activity.
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