Abstract
AbstractDogs were fed with an ulcerogenic agent, cinchophen, for 6 days and 14 days. The acid polysaccharides of the gastric wall were fractionated and the aminosugar content of the fractions was determined. After 6 days cinchophen feeding a significant increase in the amount of fractions containing chondroitin sulfuric acid B and in three fractions containing epithelial sulfopolysaccharides were noted, whereas the amount of the fraction containing hyaluronic acid showed an opposite tendency. The change in chondroitin sulfuric acid B content was the greatest in the middle sections of the mucosa of the antrum. At this time no ulcers had yet appeared.After 14 days feeding the content of chondroitin sulfuric acid B fell significantly in all parts of the gastric wall (duodenum, antrum and corpus). In antrum and duodenum it was noted that one of the epithelial polysaccharide fractions also fell. These changes were found over the whole area of the gastric and duodenal wall. The bearing of these observations on the changes in nutritional conditions in the gastric wall is discussed. It would appear that cinchophen feeding is followed by changes in the connective tissue polysaccharides, hyaluronic acid and chondroitin sulphuric acid B and that these changes take place already prior to the ulcer formation.
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