The Effect Of Cigarette Smoke On The Folliculogenesis Process In Mice (Mus Musculus)

Abstract

Nowadays, smoking is a very familiar sight. Smoking habits are considered to provide enjoyment for the smoker, however on the other hand they can cause negative effects for the smokers themselves and those around them. Research on the effects of smoking in women has not been done, whereas women, who do not smoke, are one of the victims of exposure to cigarette smoke from husbands / men who smoked. This research generally aims to study the effect of cigarette smoke on the folliculogenesis process in mice (Mus muscullus), which includes the establishment of primary follicle, secondary follicle, tertiary follicle and follicle de graaf. The research was conducted in subjects with variation of cigarette smoke dosage. K1 group as a control group was given the aroma therapy smoke to its mice. K2 group was given 1 dose / 24 hour smoke. K3 group was given 2 doses / 24 hour smoke. K4 group was given 3 doses / 24 hour smoke in all treatment groups. The hypothesis is tested with two-way analysis of variance, in which the first factor is exposure to cigarette smoke and the second is the day of observation. Exposure to cigarette smoke within 6 weeks has significant effect on the formation of primary follicle in mice. The overall exposure to cigarette smoke is 2 weeks, 4 weeks and 6 weeks that has significant effect on the formation of secondary follicle in mice. While, it has no significant effect on the formation tertiary follicle in mice. Exposure to cigarette smoke in a period of 6 weeks has no significant effect on the formation of follicle de graaf in mice.