Abstract
Cigarette-smoke condensate, usually combined with a solvent such as acetone, reportedly produces various changes when applied to animal tissues. These changes cover a wide range from mild hyperplasia to gross, metastasizing cancer. Tissues so far studied include skin, oral mucosa, bronchial mucosa, epithelium of bladder, and uterine cervix.3,7,8,10,24Most studies have been in mice, a few in hamsters, rabbits, and rats. Histologic cancer from the condensate has been reported in skin, bladder, cervix, and mouth.4,7,8,24 Of the 18 or more polycyclic hydrocarbons22identified in the condensate, 8 are reported to be carcinogenic for animals.25While some investigators emphasize that concentrations of carcinogenic hydrocarbons in the condensate (predominately benzo[a]pyrene) are not sufficient to justify rating cigarettes as a major factor in human cancer,9others feel that the complexity of the condensate, varying with different conditions of combustion in its production and containing multiple carcinogens
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