Abstract
The effect of methionine deficiency on the metabolic fate of cyanocobalamin in rats was studied. No significant differences in the absorption and excretion of orally administered 60Co-labeled cyanocobalamin were noted between methionine-deficient and methionine-supplemented groups. The retention of injected 60Co-labeled cyanocobalamin by the kidney, liver, spleen and heart of methionine-deficient rats was higher than that of methionine-supplemented rats. These results suggest that there may be an increase in the utilization of vitamin B 12 to ameliorate methionine deficiency by sparing methyl group and/or by increasing methionine synthesis.
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