Abstract
The relation of rat liver tryptophan pyrrolase activity to the number of daily injections of tryptophan has been examined. The level of this enzyme increased in response to a test injection of tryptophan throughout a 50-day period of chronic administration of tryptophan, although the magnitude of the response varied, being greater each day for the first 17 days, then decreasing to slightly less than that to a single injection by the 50th day. The same magnitude of responses of this enzyme to a single test tryptophan injection was obtained in rats injected daily with saline during the same period. However, in the reverse situation, the injection of a single dose of saline to rats chronically injected with tryptophan did not produce any greater response of pyrrolase activity than that after a single saline injection. When the activities of both apoenzyme and completely activated enzyme in the livers of rats injected with tryptophan for 19 days were compared with a similar group of rats receiving only one tryptophan injection, it was seen that the levels of both apoenzyme and activated enzyme were higher in the livers of the chronically injected rats.
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