Abstract
Abstract Chlorthalidone, in high doses, failed significantly to influence blood sugar or intravenous glucose tolerance in the rat, following the intraperitoneal injection of single doses or 28 day oral treatment with the drug (100 mg/kg daily). The significant effect of the drug in stimulating glucose transfer in everted sacs prepared from rat intestine may explain the trend towards altered oral glucose tolerance observed. Chlorthalidone failed significantly to influence the blood sugar of alloxan diabetic rats and did not modify glucose uptake by rat-hemidiaphragm muscle or epididymal adipose tissue incubated in vitro in the presence or absence of insulin.
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