Abstract
Summary Chlorphenesin administered jointly with sheep or chicken erythrocytes or with penicillin conjugates suppressed the antibody-producing capacity of isolated spleen cells as evaluated by the localized hemolysis in gel technique. The production of humoral antibodies was also depressed. The suppressive effect of chlorphenesin was dose-dependent and was also influenced by the concentration of the drug present in the chlorphenesin-antigen mixture. Administration of chlorphenesin before or after the antigen had little effect on the immune response. Chlorphenesin did not affect pre-existing antibodies and did not produce immunologic tolerance. The drug inhibited the immunologic responses to the antigen but nevertheless primed the animal, as evidenced by the rapid rise of antibodies after a booster injection of the antigen. Chlorphenesin was also able to suppress the tuberculin reaction in guinea pigs when administered at the time of challenge.
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