Abstract
Osteoarthritis (OA) is the most common articular disease world wide. It is the result of both mechanical and biological events that destabilize the normalcoupling of degeneration synthesis of articular cartilage and subchondral bone.Rheumatologist often routinely order tests for rheumatoid factor and erythrocyte sedimentation rate (ESR) for all patients with joint complaints aswell as C - reactive protein (CRP) as a laboratory marker important in the assessment of inflammation. Anti malarial drugs are used for treatment of manyrheumatic diseases. Chloroquine phosphate (CQP) was used previously as a disease modifying anti rheumatic drug and in this study its effect appearsthrough decreasing the measurement of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in knee osteoarthritic patients (KOA).Abbreviation: HCQ, hydroxy chloroquine; CQ, chloroquine; DMARD, disease modifying anti rheumatic drug; APP, acute phase protein; ACR, AmericanCollege of Rheumatology; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; RF, rheumatoid factor.
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