Abstract
After acute oral chloroquine administration in rats, there was an accumulation of membrane whorls (myeloid bodies) in certain cell organelles of the heart. Acid phosphatase staining indicated that these were lysosomal in nature. With up to six daily doses of chloroquine (120 mg/kg), the myeloid bodies increased in size and number. One week after the drug treatment was discontinued, the myeloid bodies were smaller and showed increased acid phosphatase activity. After a further 2 weeks they had disappeared, showing that the effect of the drug was reversible.
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