Abstract
Aim: This is study aimes to demonstrate the effect of chlorohexidine gelfoam on the salivary Tumor Necrosis factor and Interleukin-6 after extraction of lower third molar to compare these effect before and after extraction ' and to know the benefit of using chlorhexidine gelfoam after extraction of lower third molar . Material and method:-twenty four patients were involved, patients classified into group 1[control group],group 2 [chlorhexidine group] saliva was taken from all patients by using salivette before extraction and seven day after extraction then measure TNF andIL-6 by using [ELISA] kits' Results:- there is significance difference in (IL-6) after one week of extraction without treatment from the baseline (before extraction) and the result respectively was (1.96±0.51),( 6.20±5.22),and the result of (TNF-α) appeared no significance difference before and after treated the result after treatment is(25.9±30.8) and before treatment is (95.2±131.6) and the result of group used chlorhexidine gelfoam show significance difference in both (IL-6, TNF-α) after and before treatment, the result of IL-6 after treatment is (16.99±13.31) and before treatment is (1.57±0.18) and the result of (TNF-α) after treatment is (56±79.3) and before treatment is (102.9±133.3) Conclusion:- the use of chlorohexidine gelfoam after extraction help to decrease the salivary TNF-α. with significant difference and decrease level of IL-6 with a significant differences compare it with control group which enhance healing process and decrease the chance of infection.
Highlights
Extraction is a process that has not always been correctly measured as a consequence of the standard procedure (1) person has his or her healing ability, which is determined by his or her biotype and biological profile, consisting of cytokines and inflammation mediator. (2), Threestage healing, inflammatory phase, proliferative phase, maturation phase, the first cycle initiated as soon as blood platelets come into contact with collagen, connective tissue when blood fills in an empty socket, this produces a platelet aggregation that forms a clot this clot prevents the bleeding and considers as a help for the successive stage of cicatrization (3), The platelet cycle growth factor and mediators (Cytokines) implicated in angiogenesis (4)
Gelfoam is considered a sterile sponge as a medical tool intended for application to the bleeding surface as a hemostatic agent (9), chlorohexidine gelfoam is used as haemostatic agent, chlorhexidine is a biguanide, antiseptics, chlorhexidine is effective against both aerobic and aerobic bacteria, and leaves, chlorhexidine ransom is known to reduce the effectiveness of the oral microbe population(10), This subsequently reflects on the point of studying the impact of chlorhexidine gelfoam on the inflammatory mediator (IL-6 and TNF-α) following extraction
Effect of chlorohexidine gelfoam on salivary Tumor necrosis factor and Interleukine-6 grouped into group1[control group] twelve patients without applying gelfoam on the analgesic [500mg ]paracetamol tablet on need and asked the patient to return to dentist if any sign of dry socket has appeared as[sever pain, and bleeding]' group 2 eleven patients applied gelfoam with chlorhexidine on the socket of lower third molar and asked patient to take paracetamol tablet[500]mg as a simple analgesic on need and asked the patient to return if any sign of dry socket is appeared
Summary
Extraction is a process that has not always been correctly measured as a consequence of the standard procedure (1) person has his or her healing ability, which is determined by his or her biotype and biological profile, consisting of cytokines and inflammation mediator. (2), Threestage healing, inflammatory phase, proliferative phase, maturation phase, the first cycle initiated as soon as blood platelets come into contact with collagen, connective tissue when blood fills in an empty socket, this produces a platelet aggregation that forms a clot (erythrocytes and leukocytes embedded in fibringel) this clot prevents the bleeding and considers as a help for the successive stage of cicatrization (3), The platelet cycle growth factor and mediators (Cytokines) implicated in angiogenesis (4). Extraction is a process that has not always been correctly measured as a consequence of the standard procedure (1) person has his or her healing ability, which is determined by his or her biotype and biological profile, consisting of cytokines and inflammation mediator. (2), Threestage healing, inflammatory phase, proliferative phase, maturation phase, the first cycle initiated as soon as blood platelets come into contact with collagen, connective tissue when blood fills in an empty socket, this produces a platelet aggregation that forms a clot (erythrocytes and leukocytes embedded in fibringel) this clot prevents the bleeding and considers as a help for the successive stage of cicatrization (3), The platelet cycle growth factor and mediators (Cytokines) implicated in angiogenesis (4). Cytokines are soluble proteins that play a significant role in the initiation and maintenance of inflammatory and immune response as well as an intercellular cross-talking (5). Gelfoam is considered a sterile sponge as a medical tool intended for application to the bleeding surface as a hemostatic agent (9), chlorohexidine gelfoam is used as haemostatic agent, chlorhexidine is a biguanide, antiseptics, chlorhexidine is effective against both aerobic and aerobic bacteria, and leaves, chlorhexidine ransom is known to reduce the effectiveness of the oral microbe population(10), This subsequently reflects on the point of studying the impact of chlorhexidine gelfoam on the inflammatory mediator (IL-6 and TNF-α) following extraction
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