Abstract
The possible site of action of chlorobutanol upon the respiratory metabolism was investigated in rat heart, cerebrum, and cerebellum preparations. The behavior of this compound on respiration of slices, homogenates, and mitochondria showed that its inhibitory effect was more evident when NAD-dependent dehydrogenases were involved in the primary oxidation of substrates, although a more drastic effect of chlorobutanol on the mitochondria could be obtained, since chlorobutanol is also an antiseptic. Nevertheless, chlorobutanol in suitable amounts was used to determine its effect on the normal properties of mitochondria-respiration, oxidative phosphorylation, respiratory control coefficient—and on the steady-state levels of cytochrome b from heart sarcosomes.
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