Abstract
Angiogenesis is the growth of blood vessels from the existing vasculature [1] that occurs during embryonic development, wound healing, and the menstruation cycle. Moreover, unregulated angiogenesis...
Highlights
Angiogenesis is the growth of blood vessels from the existing vasculature that occurs during embryonic development, wound healing, and the menstruation cycle
Result: In our study, we observed that CuNPs solutions caused a significant increase in angiogenesis when compared with the control group
The study of Dragostin et al shows that chitosan nanoparticles have an anti-angiogenic effect
Summary
Angiogenesis is the growth of blood vessels from the existing vasculature [1] that occurs during embryonic development, wound healing, and the menstruation cycle. Chitosan is a natural cationic polysaccharide and one of the natural polymers and obtained by deacetylation of α-chitin [3,4]. It has been included in studies that chitosan molecule is an effective transportation tool for reaching the related target with the pharmaceutical properties of various drugs [5]. Chitosan-based nanoparticles have major effects such as anti-cancer, antibacterial, anti-angiogenesis. It was demonstrated that chitosan nanoparticles suppress lipopolysaccharide-induced inflammatory cascade, which is prominent in Crohn’s disease and ulcerative colitis [6]. It is known in the literature that chitosan has a procoagulant effect. Nanotoxicity study of chitosan nanoparticles was done in animal models. As a result of these studies, chitosan nanoparticles showed good biosafety [7]
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