Abstract
Purpose : To determine the effect of chemotherapeutic drugs on the intestinal flora of tumor-bearing mice using high-throughput sequencing technology. Methods : Twenty BALB/c nude mice were randomly divided into two experimental groups. Each experimental group was divided into a blank group and a drug group, each containing five mice. BGC823 cells were inoculated to all experimental groups. For the blank groups, physiological saline or glucose injection was used for intervention. For the drug groups, oxaliplatin or 5-fluorouracil was used for intervention. Changes in the intestinal flora of mice were detected via the high-throughput sequencing technology. Results : No significant difference in diversity between the blank and drug groups was found. A decrease in the expression of bacteroidetes was noted in the drug groups. Conclusions : The use of chemotherapeutic drugs did not significantly affect the intestinal flora diversity of tumor-bearing nude mice, but it did inhibit the expression of probiotics.
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