Abstract
Substitution of flagellin with a variety of reagents caused a reduction in antigenicity relative to unmodified flagellin. This reduction resulted in a decreased capacity (1) to elicit a primary anti-flagellin antibody response and (2) to prime for a secondary response. However compared with acetoacetylated flagellin, there was less correlation between the loss of antigenicity and the capacity of the antigen to prime for delayed-type hypersensitivity. For example, when flagellin was lightly succinylated or iodinated, the resulting antigen induced enhanced DTH. Further substitution depressed the DTH response induced. Injection of extensively iodinated flagellin into rats induced a state of partial antibody tolerance similar to that found earlier with acetoacetylated flagellin. However, iodinated flagellin which induced antibody tolerance did not prime for enhanced DTH.
Published Version
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