Abstract
Background and Aim:The presence of gastric mucosa or submucosa inflammation due to Helicobacter pylori leads to histological changes. Gastric injury, pro-inflammatory factors, and oxidative stress in H. pylori infection produce asymmetric dimethylarginine (ADMA), which are a competitive inhibitor of nitric oxide synthase. Investigations were carried out aimed at finding new drugs derived from natural products for the treatment of H. pylori. Channa striata is known to have in vitro anti-inflammatory and antimicrobial properties. This study aimed to investigate the effect of C. striata extract and a standard eradication regimen on ADMA levels and histological changes in the H. pylori gastritis rat model.Materials and Methods:Thirty-five male rats were randomly and equally divided into five groups. Group-1 was the negative control group and Groups-2 to 5 were H. pylori-infected groups. Groups-3 to 5 were administered C. striata extract, a standard eradication regimen, and a combination of standard eradication regimen and C. striata extract, respectively. Histological examination and serum ADMA levels were analyzed. The difference between groups was analyzed using the Kruskal–Wallis and one-way analysis of variance tests. The significance was p<0.05.Results:Serum ADMA levels and severity of gastritis were higher in infected groups compared to the negative control group (p<0.05). The severity of gastritis and mean ADMA levels in the group that received a single administration of the C. striata extract was higher than the others (p<0.05). Serum ADMA levels and severity of gastritis were significantly reduced in the group that received a combination of standard eradication regimen and C. striata extract (p<0.05).Conclusion:Single administration of C. striata extract worsens the severity of gastritis and increased serum ADMA levels in the H. pylori gastritis rat model. The administration of a combination of standard eradication regimen and C. striata extract reduces serum ADMA levels and significantly improves the severity of H. pylori gastritis rat model.
Highlights
Helicobacter pylori is a bacterium that causes damage to the gastric mucosa, commonly in the form of gastritis, peptic ulcer disease, or even gastric malignancy [1]
Serum asymmetric dimethylarginine (ADMA) levels and severity of gastritis were significantly reduced in the group that received a combination of standard eradication regimen and C. striata extract (p
Single administration of C. striata extract worsens the severity of gastritis and increased serum ADMA levels in the H. pylori gastritis rat model
Summary
Helicobacter pylori is a bacterium that causes damage to the gastric mucosa, commonly in the form of gastritis, peptic ulcer disease, or even gastric malignancy [1]. Gastritis is the most common clinical manifestation of H. pylori infection. The occurrence of gastric mucosa or submucosa inflammation due to H. pylori causes mild-to-severe histological changes. The degree of gastritis is related to the density of H. pylori, gastric mucosal injury, and inflammation [2]. The presence of gastric mucosa or submucosa inflammation due to Helicobacter pylori leads to histological changes. Pro-inflammatory factors, and oxidative stress in H. pylori infection produce asymmetric dimethylarginine (ADMA), which are a competitive inhibitor of nitric oxide synthase. This study aimed to investigate the effect of C. striata extract and a standard eradication regimen on ADMA levels and histological changes in the H. pylori gastritis rat model
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