Abstract
The short article entitled ‘Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures’, published in...
Highlights
The strong effects of changes in PaCO2 on the cerebral vasculature, first discovered in 1928 by Forbes and Wolff via direct observation of the pial arteries through a glass window in animals, was subsequently confirmed in humans, first indirectly by Neurology, Hopital Sainte-Anne, Paris CB2 2QQ, France
In clinical neurology and stroke medicine, the implications of the concept of maximal vasodilation has had to this day major impact in the understanding and management of cerebrovascular diseases including transient ischaemic attacks (TIAs) and acute ischaemic stroke
Thanks to the development of non-invasive techniques to measure regional cerebral blood flow (CBF) and oxygen metabolism in man using positron emission tomography, it was shown that in a subset of patients with repeated TIAs affecting the territory of an occluded or severely stenotic internal carotid artery, there was permanent hypoperfusion in the distal cortical areas associated with increased oxygen extraction fraction, documenting exhausted vasodilatory reserve in turn causing clinical symptoms on a haemodynamic—as opposed to embolic—basis.[8]
Summary
The strong effects of changes in PaCO2 on the cerebral vasculature, first discovered in 1928 by Forbes and Wolff via direct observation of the pial arteries through a glass window in animals, was subsequently confirmed in humans, first indirectly by Neurology, Hopital Sainte-Anne, Paris CB2 2QQ, France.
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