The effect of catalytic reaction conditions on the incorporation of tritium in unsaturated compounds

Abstract

AbstractWe have obtained multiple‐tritium‐labelled 5‐α‐androstan‐3‐one, dihydropicrotoxin, dimethyl‐propyl‐3‐chloro‐butyl‐ammonium chloride, 2,2‐di(trifluoromethyl)‐3,3‐dicyanobicyclohept[2,2,1]ane, dihydroalprenolol, undecanoic acid, dihydro‐m,m'‐di‐tert.‐butyl‐p‐coumaric acid and dihydrofusicoccin. By varying the conditions for the hydrogenation of terminal double bonds one can considerably increase the molar radioactivity of such compounds through isotopic exchange. We discuss some tentative explanations of the effect of the labelling reaction conditions upon the synthesis of compounds with desired properties.