THE EFFECT OF CARONAMIDE ON THE BLOOD CONCENTRATION OF PENICILLIN FOLLOWING ORAL AND INTRAMUSCULAR ADMINISTRATION OF PENICILLIN

Abstract

Article1 February 1949THE EFFECT OF CARONAMIDE ON THE BLOOD CONCENTRATION OF PENICILLIN FOLLOWING ORAL AND INTRAMUSCULAR ADMINISTRATION OF PENICILLINWILLIAM W. ZELLER, M.D., MARK H. LEPPER, M.D., JAY A. ROBINSON, M.D., HAROLD L. HIRSH, M.D., HARRY F. DOWLING, M.D., F.A.C.P.WILLIAM W. ZELLER, M.D.Search for more papers by this author, MARK H. LEPPER, M.D.Search for more papers by this author, JAY A. ROBINSON, M.D.Search for more papers by this author, HAROLD L. HIRSH, M.D.Search for more papers by this author, HARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-2-398 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the greatest problems in the clinical use of penicillin has been the maintenance of adequate plasma concentrations in spite of the rapid rate at which the antibiotic is excreted by the kidneys. Recently Sprague and his associates1have developed a drug, caronamide (4' carboxyphenylmethanesulfonanilide) which inhibits the renal excretion of penicillin. Beyer2, 3has postulated that caronamide suppresses penicillin excretion by blocking the specific enzyme system responsible for penicillin transport through the tubular cells. Since it has been demonstrated2, 4that of the penicillin excreted about 20 per cent passes into the urine through the glomeruli and 80...Bibliography1. SPRAGUEZIEGLERCRAEGOEMILLER JMCEJCS: 4 carboxyphenylmethanesulfonanilide. To be published. Google Scholar2. BEYER KH: New concept of competitive inhibition of the renal tubular excretion of penicillin, Science, 1947, cv, 94. CrossrefGoogle Scholar3. BEYERRUSSOPATCHMILLER KHHFEHAK: A new concept of competitive inhibition of penicillin, Am. Jr. Med. Sci., 1947, ccxiii, 246. Google Scholar4. RAKERICHARDSON GAP: Pharmacology of penicillin, Ann. New York Acad. Sci., 1946, xlviii, 143. CrossrefGoogle Scholar5. BEYERRUSSOMILLERPATCHVERWEY KHHFAKEAWF: The inhibitory effect of caronamide on the renal elimination of penicillin, Am. Jr. Physiol., 1947, cxlix, 355. CrossrefGoogle Scholar6. BEYERRussoPATCHTILLSON KHHFEAEA: Caronamide: Its pharmacological properties. To be published. Google Scholar7. BEYERMCKINNEYTILLSONGREEN KHSEEACW: Caronamide: Its toxicologic effects. To be published. Google Scholar8. VERWEYMILLER WFAK: The effect of caronamide upon penicillin therapy of experimental pneumococcus and typhoid infections. To be published. Google Scholar9. RAMMELKAMP CH: A method for determining the concentration of penicillin in body fluids and exudates, Proc. Soc. Exper. Biol. and Med., 1942, li, 95. CrossrefGoogle Scholar10. HILL B: Principles of Medical Statistics, Third edition, 1945, The Lancet Limited, London. Google Scholar11. SEELERWILCOXFINLAND OSCM: Enhancement of blood levels by caronamide during intramuscular administration of penicillin, Jr. Lab. and Clin. Med., 1947, xxxii, 807. Google Scholar12. STRAUSSRICHBERGSABAALEXANDER EPLPZJE: Enhancement of plasma penicillin concentrations by caronamide and sodium benzoate, Jr. Lab. and Clin. Med., 1947, xxxii, 818. Google Scholar13. SHAWBOGERCROSSENKEMPLINGDUNCAN CCWPJWWWWSGG: Enhancement of penicillin blood levels by means of a new compound, caronamide, Am. Jr. Med., 1947, iii, 206. CrossrefGoogle Scholar14. CROSSENBOGERSHAWMILLER JWWPCCAK: Caronamide and penicillin, Jr. Am. Med. Assoc., 1947, cxxxiv, 1528. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 20, 1947.From the George Washington University Medical Division, Gallinger Municipal Hospital, and the Department of Medicine, George Washington University School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnterococcal Endocarditis as a Complication of Urologic InstrumentationDie Therapie der Endocarditis lenta und ihre GrundlagenSyphilis 1 February 1949Volume 30, Issue 2Page: 398-407KeywordsAttentionBlood plasmaDrugsEnzymesExcretionHospital medicineKidneysPenicillinTubular cellsUrine ePublished: 1 December 2008 Issue Published: 1 February 1949 PDF downloadLoading ...