Abstract
THE investigations by Hewitt, White, Wallace, Stewart, Kushner and SubbaRow (1947) and Hewitt, Kushner, Stewart, White, Wallace and SubbaRow (1947) showed that 1-diethylcarbamyl-4-methylpiperazine hydrochloride (Caricide) had a marked effect against Litomosoides carinii infections in rats. The same substance had a similar influence upon Dirofilaria immitis in dogs (Hewitt, Kushner, Stewart, White, Wallace and SubbaRow, 1947); Wuchereria bancrofti in man (Santiago-Stevenson, Oliver-Gonzalez and Hewitt, 1947); and adult Trichinella spiralis in white rats (Oliver-Gonzalez and Hewitt, 1947).In studies of ascariasis, Kanegis (1948) reported that in cats diethylcarbamazine dihydrogen citrate approached 100 percent efficiency. He stated that the optimum dose was 25 mg. per pound of body weight. Hewitt, Wallace, White and SubbaRow (1948) obtained similar results in dogs infected with ascarids. Caricide was also shown by Oliver-Gonzalez and Hewitt (Hewitt, Wallace, White and SubbaRow, 1948) to possess activity against Ascaris Lumhricoides infections in man.The purpose of the present investigation was .
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