Abstract
Pretreatment of young rats with phenobarbital, dichlorodiphenyltrichloroethane (DDT), gammexane, and carcinogenic polycyclic hydrocarbons, stimulates the O-dealkylation of 2- and 4-alkoxybiphenyls by rat liver microsomes. Phénobarbital, gammexane, and DDT stimulate the activity 80–178 per cent, the degree of stimulation being independent of the length of the alkyl side chain of the substrate. Imipramine, meprobamate, and butylatedhydr oxytoluene (BHT) have little or no effect at the dose level used. The degree of stimulation by carcinogenic hydrocarbons increases with increase in substrate side-chain length from 0 to 70 per cent for CH 3O- to over 300 per cent for C 4H 9O-. Noncarcinogenic hydrocarbons do not show this inductive pattern and are mostly without significant effect.
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