Abstract
There is effect of Carbimazole on oxidative stress with Hyperthyroidism. To assess the oxidative stress and total antioxidant capacity in hyperthyroid patient and evaluate the effect of Carbimazole on oxidative stress and total antioxidant status. Case series study design. The study was conducted in departments of general surgery outpatient private clinic of and AL-Jumhori teaching hospital. The study period between Dec .1st, 2020 and April.1st, 2021. Thirty patients newly diagnosed with hyperthyroidism and thirty healthy volunteers as control group were participated in the study. Malondialdehyde (MDA) and total antioxidant status (T-AOC) were measured control group and also measured in patients with hyperthyroidism before and after taking Carbimazole therapy for two months duration. Indicated an increase in mean serum MDA level (4.74 ± 3.62 ng/ml), also there was a significantly lower level of T-AOC (6.72 ± 3.08 U/ml) in patients with HTH disorder before therapy in comparison with the control group (1.83 ± 0.47 ng/ml), (10.38 ± 2.32 U/ml), respectively. After two months of antithyroid therapy (Carbimazole), there was a significant reduction in MDA levels (2.51 ± 1.99 ng/ml),(P-value = 0.001) and a significant increase in serum T-AOC level (8.57 ± 3.09 U/ml), (P-value = 0.001) in comparison to their values before therapy. The present study demonstrated that hyperthyroid patients have increased level of malondialdehyde and decreased levels of total antioxidants capacity than the control group while hyperthyroid patients treated with Carbimazole for two months have decreased level of MDA and increased levels of T-AOC than their levels before treatment. This result may give a new insight that Carbimazole may exhibit its effect in the management of hyperthyroidism by acting as an antioxidant.
Highlights
Hyperthyroidism is a state of reduced thyroid stimulating hormone (TSH) concentration and where there is an increase in the secretion of thyroid hormone triiodothyronine (T3) and tetraiodothyronine (T4) by thyroid gland, which are involved in maintaining various metabolism cycles, and (Costilla et al, 2019 ).Thyroid hormones are the most important factors involved in oxidative metabolism( Joshi et al, 2018)
The present study demonstrated that hyperthyroid patients have increased level of malondialdehyde and decreased levels of total antioxidants capacity than the control group while hyperthyroid patients treated with Carbimazole for two months have decreased level of MDA and increased levels of T-AOC than their levels before treatment
The oxidative stress in hyperthyroid individuals was assessed by measuring plasma levels of a lipid peroxidation byproduct, malondialdehyde (MDA), the most generally used oxidative stress indicator, and the plasma antioxidant state was assessed by measuring total antioxidant capacity (T-AOC)
Summary
Hyperthyroidism is a state of reduced thyroid stimulating hormone (TSH) concentration and where there is an increase in the secretion of thyroid hormone triiodothyronine (T3) and tetraiodothyronine (T4) by thyroid gland, which are involved in maintaining various metabolism cycles, and (Costilla et al, 2019 ). Thyroid hormones are the most important factors involved in oxidative metabolism( Joshi et al, 2018). Thyroid hormones synthesis includes a radical intermediate, creating a need for a ROS reaction as part of the organ’s function to maintain homeostasis. Iodination of tyrosine residues, catalyzed by a peroxidase enzyme, occurs on the endoplasmic reticulum of the thyroid gland cells ( Carrasco ,2005). Thyroid tissue has been found to have high levels of oxidative stress, which has been linked to hyperthyroidism (Mancini et al.,2016)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
