Abstract
BackgroundWith the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacological therapy can significantly improve the heart rate recovery and survival rate of patient. However, the effect of pharmacological therapy on the cardiovascular hemodynamic states with LVAD support is still unclear.MethodsIn this study, pharmacokinetic model of captopril is established to describe the relationship between plasma–drug concentration and time. Then, combination model, consisting of pharmacokinetic model of captopril and lumped parameter model of cardiovascular system with BJUT-II VAD support, is established to mimic the effect of pharmacological therapy on cardiovascular hemodynamics. BAI control strategy and HR control strategy for BJUT-II VAD are chosen to evaluate their performance by the combination model.ResultsThe simulation results demonstrate that the concentration of captopril could affect the pressure and heart rate by changing the peripheral resistance, and then affect the performance of BJUT-II VAD in a short duration. Under the regulation of control strategies of BJUT-II VAD, the hemodynamic states of cardiovascular system returned to the standard value in 10 s.ConclusionThis study could provide useful information about how to design coupled strategy of LVAD support and pharmacological therapy.
Highlights
With the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers
In order to evaluate the effect of the captopril on the performance of the control strategy, three numerical simulations are conducted
The simulation results demonstrate that the combination model can reflect the effect of captopril on the hemodynamics of cardiovascular system
Summary
With the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. The combination of LVAD and pharmacological therapy can significantly improve the heart rate recovery and survival rate of patient. Left ventricular assist devices (LVAD) have been widely used in the clinical. Giridharan et al [1] proposed a physiological controller using the mean differential pressure between the left ventricle and the aorta to regulate pump speed. Boston et al [2] designed a hierarchical controller to remain the pulsatility of the pump flow signal by the pump speed. Arndt et al [3] proposed full or partial assistance mode of LVAD by the gradient of differential pressure pulsatility to classify two specific operating modes. Wu et al [4] proposed a physiological adaptive controller by calculating the change of peripheral resistance
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