Abstract
Extract: Functional and morphologic studies of fibrin formation in the presence of a variety of cancer chemotherapeutic agents in vitro showed that some of these drugs cause fibrinolysis, inactivation of fibrin-stabilizing factor (FSF), or a combination of both. The drugs with most potent activity are 5-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide (TIC mustard), 5-fluorouracil, nitrogen mustard, adriamycin, and daunomycin. These changes were dose related.Speculation: Interference with fibrin formation by anticoagulation has been associated with reduced implantability of tumor emboli in experimental systems. This study presents evidence that some cancer chemotherapeutic agents have chemical properties of an anticoagulant nature. In addition to any influence on cell multiplication, high pulse doses of adjuvant chemotherapy at the time of tumor manipulation such as surgery may interfere with fibrin formation around tumor emboli and discourage metastatic implantation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
