Abstract
Calcium added to the solution bathing the outside of isolated frog skin caused a reversible decrease in net sodium transport across the skin. At constant sodium concentration, the inhibition of transport increased with increasing calcium concentration, but approached a limiting value. This maximum degree of inhibition was found to depend on sodium concentration; sodium transport could be inhibited by 60 per cent at 96 mM sodium, but by only 18 per cent at 19 mM sodium. The relative effectiveness of a given calcium concentration was also greater the higher the sodium concentration. The unidirectional flux of chloride across the short-circuited skin was decreased by calcium to approximately the same degree as active sodium transport. The results have been interpreted in terms of a relatively non-specific decrease in permeability of the outward facing membrane of the transporting cells. The resulting decrease in sodium permeability apparently causes a decrease in active sodium transport by reducing the availability of sodium to the transporting system.
Highlights
Calcium added to the solution bathing the outside of isolated frog skin caused a reversible decrease in net sodium transport across the skin
Calcium was added to solutions bathing both sides of the skin
The effect of calcium added to the outside solution was studied keeping calcium concentration of the inside solution ~zero."
Summary
Calcium added to the solution bathing the outside of isolated frog skin caused a reversible decrease in net sodium transport across the skin. Net sodium transport across the skin, as measured by the short-circuit current [5], was determined as a function of the calcium concentration of the bathing solutions.
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