Abstract
Background: Cellular response of dental pulp to existing lesions, caused by infiltration of inflammatory cells that migrate from blood vessels to the site of injury. Macrophages are the cells that most appear when inflammation occurs. Treatment for maintaining pulp tissue vitality is called pulp capping. Calcium hydroxide as a pulp capping material has the ability to trigger the growth of dentin bridges or remineralization, but calcium hydroxide can induce migration and proliferation of inflammatory cells. Currently the field of dentistry is developing propolis as an alternative pulp capping material. That is because propolis has anti-inflammatory properties. Objective: To analyze the effect of the combination of calcium hydroxide-propolis on the number of macrophage cells in the teeth of wistar rats with pulp perforation. Method: This study used 30 samples of Wistar rats which were preparated until perforation and then divided into 3 groups. The first group continued with filling with cention, the second group continued with application of calcium hydroxide and filled with cention, and the third group continued with the application of combination of calcium hydroxide and propolis and then being filledwithcention. Macrophage cell is calculated histopathologically by using compound light microscope on the 3rd day with 400x magnification. Results: The Kruskal-Wallis test results showed significant differences in macrophages after the combination of calcium hydroxide and propolis (p = 0,000). The combined application of calcium hydroxide and propolis showed higher macrophages than the application of calcium hydroxide and the control group. Conclusion: Application of calcium hydroxide - propolis combination was proven increase the number of macrophage cells in Wistar Rats (Rattus Norvegicus) with pulp perforation
Highlights
Based on Indonesia Health Profile data in 2011 showed that the pulp disease ranked fourth out of the ten most diseases that occur in outpatients in hospitals in Indonesia with the number of visits as many as 209 637 patients
From the calculations it was found that the average macrophage cells in the control group was 5
The average macrophage cells in treatment group 2, namely the group given a combination of calcium hydroxide-propolis, amounted to 9.7
Summary
Based on Indonesia Health Profile data in 2011 showed that the pulp disease ranked fourth out of the ten most diseases that occur in outpatients in hospitals in Indonesia with the number of visits as many as 209 637 patients. The inflammatory phase begins shortly after the injury until 3 days after the wound is characterized by haemostasis and inflammation. In this phase macrophages migrate to the injured area and phagocyted necrotic tissue 2. Calcium hydroxide as a pulp capping material has the ability to trigger the growth of dentin bridges or remineralization, but calcium hydroxide can induce migration and proliferation of inflammatory cells. Purpose: To analyze the effect of the combination of calcium hydroxide-propolis on the number of macrophage cells in the teeth of Wistar rats with pulp perforation. Conclusion: Application of calcium hydroxide - propolis combination was proven increase the number of macrophage cells in Wistar Rats (Rattus Norvegicus) with pulp perforation
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