Abstract
AimTo investigate the chemical interaction of calcium hydroxide with the corticosteroid triamcinolone acetonide in Ledermix® Paste and in Odontopaste®, a new steroid/antibiotic paste.MethodologyValidated methods were developed to analyse the interaction of calcium hydroxide in two forms, Pulpdent® Paste and calcium hydroxide powder, with triamcinolone acetonide within Odontopaste® and Ledermix® Paste. High-performance liquid chromatography (HPLC) was used to analyse the mixed samples of the pastes and calcium hydroxide. The concentration of triamcinolone acetonide within the pastes was determined over 0, 2, 6, 24 and 72-h time-points. All tests with the HPLC involved the testing of the standard with triplicate injections alongside the samples. All samples were tested in duplicate with each injected twice; therefore, four tests were performed for each investigation. Linearity, precision and specificity of the testing procedures and apparatus were validated. Descriptive statistics are provided.ResultsIn both pastes, there was a marked rapid destruction of the triamcinolone acetonide steroid upon mixing with calcium hydroxide. Odontopaste® suffered a lower rate of destruction of the triamcinolone acetonide component than Ledermix® Paste, but both pastes showed very similar degrees of steroid destruction after 72 h. When using calcium hydroxide powder with Ledermix® Paste, the triamcinolone was destroyed entirely and immediately.ConclusionThe addition of calcium hydroxide to Odontopaste® or Ledermix® Paste results in the rapid destruction of the steroid.
Highlights
Calcium hydroxide paste is a root canal medicament that has been used in endodontics for many years
The main difference between OdontopasteÒ and LedermixÒ Paste is that clindamycin hydrochloride in OdontopasteÒ replaces demeclocycline hydrochloride in LedermixÒ Paste
The time-point testing results for the percentage of triamcinolone acetonide when OdontopasteÒ and LedermixÒ were mixed with calcium hydroxide powder British Pharmacopoeia (BP) grade are listed in Table 6 demonstrating rapid loss of the steroid
Summary
Calcium hydroxide paste is a root canal medicament that has been used in endodontics for many years. It exhibits antibacterial properties and has the ability to stimulate hard tissue repair within bone and cementum (Heithersay 1975, Tronstad et al 1981). OdontopasteÒ (Australian Dental Manufacturing, Kenmore Hills, Qld, Australia) has recently been released onto the dental market, for its anti-inflammatory effect. Clindamycin hydrochloride has an equivalent spectrum of antibacterial activity but exhibits minimal staining of teeth (Adamidou 2010)
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