The effect of black seed raisin on some cardiovascular risk factors, serum malondialdehyde, and total antioxidant capacity in hyperlipidemic patients: a randomized controlled trials.

Abstract

The lipid-lowering properties and antioxidants of the raisins may reduce the risk factors of cardiovascular diseases. This study aimed to investigate the effect of black seeded raisin consumption on blood pressure (BP), lipid profile, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and serum total antioxidant capacity (TAC) in hyperlipidemic patients. Thirty-eight hyperlipidemic patients aged 41.05±10.4years were recruited to this two-armed, randomized, controlled intervention trial. Participants were instructed to consume 90g per day black seed raisin in the intervention group, and control group received no intervention. BP, lipid profile, and plasma levels of TAC, MDA, hs-CRP, and FBS were determined at baseline and week 5. After 5weeks, the diastolic BP reduced significantly in raisin group compared with baseline (81.80±10.22 vs 77.05±11.03, P=0.001) and TAC was significantly increased in raisin group compared with thecontrol group (394±116.93 vs 479±122.31, P=0.001). The serum level of MDA in the raisin group was significantly lower compared with the control group (1.35±0.88 vs 1.39±0.67, P=0.039). No significant changes were found in lipid profile, SBP, hs-CRP, and FBS. These results suggest that consumption of black raisin which is rich in polyphenolic compounds has beneficial effects on some cardiovascular risk factors especially blood pressure and serum antioxidant capacity in patients with hyperlipidemia. Trial registration number: IRCT2015091624049N1. This study was registered in the Iranian Registry of Clinical Trials (IRCT).URL of trial registry record: https://www.irct.ir/trial/20395.