The Effect of Bisphosphonate [Pamidronate] On Orthodontic Tooth Movement in Rabbits

Abstract

OBJECTIVES: The purpose of this study is to investigate the influence of local administration of bisphosphonate i.e.pamidronate (antiresorptive drug), during orthodontic tooth movement in experimental albino Newzealand rabbits. MATERIALS AND METHODS: The current study was conducted on 20 male Newzealand albino rabbits of 3.75 to 4 kg wt for a period of three weeks (21days). Animals were equally divided into 2 groups ( Group-1 Control & Group-2 Experimental ).Orthodontic appliance of 100gm force Nitinol closed coil spring was stretched and placed between mandibular molar and incisors in either group of animals. Bisphosphonate (Pamidronate) was injected mesial to the mandibular molar in the mucoperiosteal area. On the last day i.e. 21 st day of the study all animals were sacrificed and mandibles were dissected from both groups along with the appliance. The amount of mesial drift of molar was found clearly in the dissected mandibles and measured with flexible manual scale. RESULTS: On 21 st day of experiment, both groups of animals were sacrificed and the diastema was measured between 1 st and 2 nd molar on dissected mandibles. In this study the statistical analysis was done by Student 't'test . The statistical analysis has shown a significant difference between the control (4.960 ± 0.455 mm) and the experimental group (2.389 ± 0.362 mm). CONCLUSION: The present study was concluded that locally injected bisphosphonate -pamidronate had reduced molar tooth movement in rabbits, this concept may be applicable in near future for the purpose of orthodontic anchorage